## [Principal Scientist II - Pharmacology](/req-10079403-principal-scientist-ii-pharmacology "Principal Scientist II - Pharmacology") Job ID REQ-10079403 Jul 09, 2026 LOC_US ### About the Role Responsibilities: - Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities - Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions - Manage associate-level scientists - Collaborate with cross-functional project teams - Critically analyze and present results within a multidisciplinary team environment - Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook Qualifications: - PhD with 5-8 years of research experience as a postdoc or in the pharmaceutical/biotech industry - Deep knowledge of antibody drug conjugates - Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models - Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry - Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Prism and Excel - Novartis Compensation and Benefit Summary: The salary for this position is expected to range between $126,000 and $234,000 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. ### Role Requirements **Why Novartis:** Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? [https://www.novartis.com/about/strategy/people-and-culture](https://www.novartis.com/about/strategy/people-and-culture "https://www.novartis.com/about/strategy/people-and-culture") **Benefits and Rewards:** Learn about all the ways we’ll help you thrive personally and professionally. [Read our handbook (PDF 30 MB)](https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf) Division DIV_RE Business Unit Research Location LOC_US Site Cambridge (USA) Company / Legal Entity U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc. Functional Area FCT_RD Job Type Full time Employment Type Regular Shift Work No [Apply to Job](https://novartis.wd3.myworkdayjobs.com/en-US/Novartis_Careers/job/Cambridge-USA/Principal-Scientist-II---Pharmacology_REQ-10079403-1 "Apply to Job") ![careers default image](https://prod1.jobapi.novartis.com.cn/themes/custom/cosmos/patterns/images/careers-default-image.webp "careers default image") Job ID REQ-10079403 ### Principal Scientist II - Pharmacology [Apply to Job](https://novartis.wd3.myworkdayjobs.com/en-US/Novartis_Careers/job/Cambridge-USA/Principal-Scientist-II---Pharmacology_REQ-10079403-1 "Apply to Job")